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Article

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.

Genes & development - 15 Aug 2008

Kwon Mijung, Godinho Susana A, Chandhok Namrata S, Ganem Neil J, Azioune Ammar, Thery Manuel, Pellman David

Abstract excerpt

Multiple centrosomes in tumor cells create the potential for multipolar divisions that can lead to aneuploidy and cell death. Nevertheless, many cancer cells successfully divide because of mechanisms that suppress multipolar mitoses. A genome-wide RNAi screen in Drosophila S2 cells and a secondary analysis in cancer cells defined mechanisms that suppress multipolar mitoses. In addition to proteins that organize...

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Identifiers

PMID: 18662975
DOI: 10.1101/gad.1700908
PMCID: PMC2518815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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