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Novel insights into the structure and evolution of the human SAGA complex by affinity-ligand purification

2025-08-02

Abstract excerpt

Human SAGA is a 20-subunit complex that stimulates transcription and is essential for development. The most prominent addition to SAGA in metazoans compared to yeast is a 150kDa splicing-factor module (SPL). SPL is also a part of the U2snRNP but its role in SAGA is elusive, partially due to absence of high-resolution structural information regarding its incorporation into the complex. In yeast, subunit TAF5 and TA...

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Identifiers and source

Literature Corpus work
c053c603-5d72-5eef-b566-97c8842ee991
DOI
10.1101/2025.07.31.667873
Open publication

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Novel insights into the structure and evolution of the human SAGA complex by affinity-ligand purificationDOI 10.1101/2025.07.31.667873
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