Article

Diverse processes drive the origination and maturation of super-enhancers/super-silencers during a vast evolutionary timescale of a bicistronic gene

2026-03-13

Abstract excerpt

A central question in molecular genetics concerns how transcriptional regulatory sequences and de novo genes originate and reach evolutionary fixation. In this study, we utilize the human bicistronic gene SMIM45 as a model to analyze the evolutionary trajectories of gene development. This locus comprises several functional units: three enhancers (one featuring an embedded silencer), an exonic silencer that parti...

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Literature Corpus work: 722a93e3-29c1-5c0e-bd68-062093426747
DOI: 10.64898/2026.03.09.710545

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Diverse processes drive the origination and maturation of super-enhancers/super-silencers during a vast evolutionary timescale of a bicistronic geneDOI 10.64898/2026.03.09.710545Read

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