Back to search

Article

A recently evolved TAF8 isoform arising from an <i>Alu</i> insertion increases TFIID assembly complexity in the human lineage

2026-01-19

Abstract excerpt

Despite its centrality in regulating RNA polymerase II transcription in all eukaryotes, the TFIID general transcription factor exhibits several layers of variability across different tissues and developmental stages, representing an underexplored hub of evolutionary innovation. Here, we describe a novel short isoform of TAF8 (TAF8s) — a TFIID scaffold subunit — which evolved from the use of an intronic polyadenyla...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ea6654ec-41e5-5c3d-94db-4c04193d0939
DOI
10.64898/2026.01.19.699933
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A recently evolved TAF8 isoform arising from an <i>Alu</i> insertion increases TFIID assembly complexity in the human lineageDOI 10.64898/2026.01.19.699933
Sequence Analysis and Characterization of Active Human Alu Subfamilies Based on the 1000 Genomes Pilot Project.Semantic proximity
A human-specific structural variation at the <i>ZNF558</i> locus controls a gene regulatory network during forebrain developmentSemantic proximity
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.Semantic proximity
Transposable element-driven transcript diversification and its relevance to genetic disorders.Semantic proximity
<i>Taf1</i> expression in mouse: novel transcripts and protein distributionSemantic proximity
Structural variation, selection, and diversification of the <i>NPIP</i> gene family from the human pangenomeSemantic proximity
Homozygous TAF8 mutation in a patient with intellectual disability results in undetectable TAF8 protein, but preserved RNA polymerase II transcription.Semantic proximity
Alu elements: know the SINEs.Semantic proximity
Evidence for large diversity in the human transcriptome created by Alu RNA editing.Semantic proximity
Disordered but Different: Functional and Evolutionary Divergence of Transcription Factor Intrinsically Disordered RegionsSemantic proximity
TFIIIC binding to Alu elements controls gene expression via chromatin looping and histone acetylationSemantic proximity
Disease-associated AIOLOS variants lead to immune deficiency/dysregulation by haploinsufficiency and redefine AIOLOS functional domainsSemantic proximity
Select a neighboring publication to make it the new centre.