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Mitochondria in complex psychiatric disorders: Lessons from mouse models of 22q11.2 deletion syndrome

3 Jan 2017

Abstract excerpt

Mitochondrial ATP synthesis, calcium buffering, and trafficking affect neuronal function and survival. Several genes implicated in mitochondrial functions map within the genomic region associated with 22q11.2 deletion syndrome (22q11DS), which is a key genetic cause of neuropsychiatric diseases. Although neuropsychiatric diseases impose a serious health and economic burden, their etiology and pathogenesis remain...

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PMID: 28044359
DOI: 10.1002/bies.201600177

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