Article

The anti-sigma factor MucA is required for viability in <i>Pseudomonas aeruginosa</i>

2020-08-18

Abstract excerpt

<h4>ABSTRACT</h4> During decades-long infections in the cystic fibrosis (CF) airway, Pseudomonas aeruginosa undergoes selection. One bacterial genetic adaptation often observed in CF isolates is mucA mutations. MucA inhibits the sigma factor AlgU. Mutations in mucA lead to AlgU misregulation, resulting in a mucoid phenotype that is associated with poor CF disease outcomes. Due to its ability to be mutated, mu...

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Literature Corpus work: cc5dd8e5-3b53-57ef-a1ee-781f0c1940f9
DOI: 10.1101/2020.08.17.253617

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