Article

Alginate-regulating genes are identified in the clinical cystic fibrosis isolate of <i>Pseudomonas aeruginosa</i> PA2192

2018-05-10

Abstract excerpt

<h4>ABSTRACT</h4> Cystic fibrosis (CF) is a genetic disorder that leads to a buildup of mucus in the lungs ideal for bacterial colonization. When Pseudomonas aeruginosa enters the CF lung, it undergoes a conversion from nonmucoid to mucoid; colonization by a mucoid strain of P. aeruginosa greatly increases mortality. The mucoid phenotype is due to the production of alginate. The regulator of alginate production...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1181f3c3-8874-5f31-af21-4431ab5ff61b
DOI: 10.1101/319004

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Alginate-regulating genes are identified in the clinical cystic fibrosis isolate of <i>Pseudomonas aeruginosa</i> PA2192DOI 10.1101/319004Read

A complex multilevel attack on Pseudomonas aeruginosa algT/U expression and algT/U activity results in the loss of alginate production.Semantic proximity Read

Mucoid Pseudomonas aeruginosa in cystic fibrosis: characterization of muc mutations in clinical isolates and analysis of clearance in a mouse model of respiratory infectionSemantic proximity Read

Overproduction of the AlgT sigma factor is lethal to mucoid <i>Pseudomonas aeruginosa</i>Semantic proximity Read

Investigation of the algT operon sequence in mucoid and non-mucoid Pseudomonas aeruginosa isolates from 115 Scandinavian patients with cystic fibrosis and in 88 in vitro non-mucoid revertants.Semantic proximity Read

Identification of <i>Pseudomonas aeruginosa</i> genetic determinants that connect redox metabolism to alginate biosynthesisSemantic proximity Read

Mucoid<i>Pseudomonas</i>in Cystic FibrosisSemantic proximity Read

Mutations in the mucA gene of Pseudomonas aeruginosa promote disease exacerbation.Semantic proximity Read

Mechanism of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients.Semantic proximity Read

Adaptation of Pseudomonas aeruginosa to the chronic phenotype by mutations in the algTmucABD operon in isolates from Brazilian cystic fibrosis patientsSemantic proximity Read

ClpXP proteases positively regulate alginate overexpression and mucoid conversion in Pseudomonas aeruginosa.Semantic proximity Read

Different mutations in mucA gene of Pseudomonas aeruginosa mucoid strains in cystic fibrosis patients and their effect on algU gene expression.Semantic proximity Read

The anti-sigma factor MucA is required for viability in <i>Pseudomonas aeruginosa</i>Semantic proximity Read