Mutations in the mucA gene of Pseudomonas aeruginosa promote disease exacerbation.

Abstract excerpt

The mucA gene is a major genetic determinant of mucoid conversion in Pseudomonas aeruginosa isolated from patients with cystic fibrosis (CF) and represents a frequent hotspot for adaptive mutations. Although the role of the mucA gene in pathogen adaptation and virulence has been progressively elucidated, a comprehensive and systematic synthesis of its emerging functions and regulatory networks remains lacking....

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