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Article

ATF5 regulates β-cell survival during stress

23 Jan 2017

Abstract excerpt

The stress response and cell survival are necessary for normal pancreatic β-cell function, glucose homeostasis, and prevention of diabetes. The homeodomain transcription factor and human diabetes gene pancreas/duodenum homeobox protein 1 (Pdx1) regulates β-cell survival and endoplasmic reticulum stress susceptibility, in part through direct regulation of activating transcription factor 4 (Atf4). Here we show that...

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Share to Endoplasmic Reticulum Stress and Disease
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PMID: 28115692
DOI: 10.1073/pnas.1620705114

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