Article

ER stress and cell fate: FKBP2 regulates proinsulin folding and α- vs. β cell differentiation via NFAT and HDAC9

2025-09-03

Abstract excerpt

The continuous demand for insulin production places a burden on the endoplasmic reticulum (ER) of pancreatic β cells, making them highly susceptible to protein misfolding and ER stress. While general ER chaperones are known to be essential for β cell homeostasis, the specific mechanisms by which individual chaperones facilitate proinsulin folding and influence cell fate remain unclear. This study identifies FK506-...

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Identifiers and source

Literature Corpus work: a9341946-9c51-58a5-9970-f3aa5b6393b3
DOI: 10.1101/2025.09.01.672695

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