Article

Type 2 diabetes susceptibility gene GRK5 regulates physiological pancreatic β-cell proliferation via phosphorylation of HDAC5 in mice

2022-12-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Diabetes onset is accompanied with β-cell deficiency, and thus restoring functional β-cell mass is a promising therapy for those with diabetes. However, the regulatory mechanisms controlling β-cell mass are not fully understood. Previously, we demonstrated that the transcription factor SOX4 is required for β-cell proliferation in the prediabetic state. To elucidate potential...

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Literature Corpus work: 67c7899f-fbcd-5c16-bbe4-e2a47e39bae3
DOI: 10.1101/2022.12.23.521810

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