Article

Loss of Tet2 affects proliferation and drug sensitivity through altered dynamics of cell-state transitions

2020-01-20

Abstract excerpt

<h4>Summary</h4> A persistent puzzle in cancer biology is how mutations, which neither alter canonical growth signaling pathways nor directly interfere with drug mechanism, can still recur and persist in tumors. One notable example is the loss-of-function mutation of the DNA demethylase Tet2 in acute myeloid leukemias (AMLs) that frequently persists from diagnosis through remission and relapse (Rothenberg-Thurley...

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Literature Corpus work: cc19809a-1ea2-5ef1-969e-29296a627723
DOI: 10.1101/2020.01.20.911834

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