Article

Biallelic <i>TET2</i> mutation sensitizes to 5’-azacitidine in acute myeloid leukemia

2021-07-18

Abstract excerpt

Precision medicine can significantly improve outcomes for cancer patients, but implementation requires comprehensive characterization of tumor cells to identify therapeutically exploitable vulnerabilities. Here we describe somatic biallelic TET2 mutation (focal deletion and nonsense mutation) in an elderly patient with acute myeloid leukemia (AML) that was chemoresistant to anthracycline and cytarabine, but acutel...

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Literature Corpus work: b8026568-7531-587e-b8c9-8dae59972f59
DOI: 10.1101/2021.07.14.21259597

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