Article

The impact of extracellular matrix on the precision medicine utility of pancreatic cancer patient-derived organoids

2023-01-27

Abstract excerpt

The use of patient-derived organoids (PDOs) to characterize therapeutic sensitivity and resistance (pharmacotyping) is a promising precision medicine approach. The potential of this approach to inform clinical decisions is now being tested in several large multi-institutional clinical trials. PDOs are cultivated in extracellular matrix from basement membrane extracts (BMEs) that are most commonly acquired commerci...

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Literature Corpus work: cc153990-9a8a-50b7-aa70-cd78d36d362d
DOI: 10.1101/2023.01.26.525757

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