Article

Establishing 3D Organoid Models from Patient-Derived Conditionally Reprogrammed Cells to Bridge Preclinical and Clinical Insights in Pancreatic Cancer

2025-01-15

Abstract excerpt

<title>Abstract</title> <p>Background Pancreatic cancer is a highly lethal malignancy with limited treatment response. Despite advancements in treatment, systemic chemotherapy remains the primary therapeutic approach for over 80% of patients, with no established biomarkers to guide drug selection. Traditional two-dimensional (2D) culture models fail to replicate the tumor microenvironment, necessitating the deve...

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Literature Corpus work: fe926692-6243-56f4-aca6-4a95e825e95f
DOI: 10.21203/rs.3.rs-5823082/v1

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