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Article

Substrate binding by the yeast Hsp110 nucleotide exchange factor and molecular chaperone Sse1 is not obligate for its biological activities.

Molecular biology of the cell - 15 Jul 2017

Garcia Veronica M, Nillegoda Nadinath B, Bukau Bernd, Morano Kevin A

Abstract excerpt

The highly conserved heat shock protein 70 (Hsp70) is a ubiquitous molecular chaperone essential for maintaining cellular protein homeostasis. The related protein Hsp110 (Sse1/Sse2 in Saccharomyces cerevisiae) functions as a nucleotide exchange factor (NEF) to regulate the protein folding activity of Hsp70. Hsp110/Sse1 also can prevent protein aggregation in vitro via its substrate-binding domain (SBD), but the...

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Identifiers

PMID: 28539411
DOI: 10.1091/mbc.E17-01-0070
PMCID: PMC5509420

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