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E484K and N501Y SARS-CoV 2 spike mutants Increase ACE2 recognition but reduce affinity for neutralizing antibody.

International immunopharmacology - 1 Jan 2022

Chakraborty Sandipan

Abstract excerpt

SARS-CoV2 mutants B.1.1.7, B.1.351, and P.1 contain a key mutation N501Y. B.1.135 and P.1 lineages have another mutation, E484K. Here, we decode the effect of these two mutations on the host receptor, ACE2, and neutralizing antibody (B38) recognition. The N501Y RBD mutant binds to ACE2 with higher affinity due to improved π-π stacking and π-cation interactions. The higher binding affinity of the E484K mutant is...

Topics

Angiotensin-Converting Enzyme 2
Antibodies, Neutralizing
Antibody Affinity
Binding Sites
Crystallography, X-Ray
Humans
Mutation
SARS-CoV-2
Spike Glycoprotein, Coronavirus
Virus Internalization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34915409
DOI: 10.1016/j.intimp.2021.108424
PMCID: PMC8641390

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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