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Article

Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function.

Nature structural & molecular biology - 1 Sept 2021

Yang Tzu-Jing, Yu Pei-Yu, Chang Yuan-Chih, Liang Kang-Hao, Tso Hsian-Cheng, Ho Meng-Ru, Chen Wan-Yu, Lin Hsiu-Ting, Wu Han-Chung, Hsu Shang-Te Danny

Abstract excerpt

The B.1.1.7 variant of SARS-CoV-2 first detected in the UK harbors amino-acid substitutions and deletions in the spike protein that potentially enhance host angiotensin conversion enzyme 2 (ACE2) receptor binding and viral immune evasion. Here we report cryo-EM structures of the spike protein of B.1.1.7 in the apo and ACE2-bound forms. The apo form showed one or two receptor-binding domains (RBDs) in the open...

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Share to Angiotensin-Converting Enzyme 2
Share to Antibodies, Neutralizing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cryoelectron Microscopy

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Share to Spike Glycoprotein, Coronavirus

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PMID: 34385690
DOI: 10.1038/s41594-021-00652-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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