Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural Analysis of the SARS-CoV-2 Spike N-Terminal Domain Across Wild-Type and Recent Variants: A Comparative Study.

Proteins - 1 Nov 2025

Quaranta Miriana, Via Allegra, Pascarella Stefano

Abstract excerpt

Since its first appearance in China, the molecular evolution of SARS-CoV-2 has progressed through altering the properties of the Spike protein, changing the virus ability to transmit and to evade host immune surveillance. Despite receiving less attention than the Receptor Binding Domain (RBD), the Spike N-Terminal Domain (NTD) is crucial to SARS-CoV-2 biology and pathogenesis. This study provides a comparative...

Topics

Join the communities discussing this publication.

Antibodies, Neutralizing
Antibodies, Viral
COVID-19
Molecular Dynamics Simulation
Protein Domains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spike Glycoprotein, Coronavirus

Static Electricity

Source

Open in PubMed Open full text

Identifiers

PMID: 40485545
DOI: 10.1002/prot.26855
PMCID: PMC12517252

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural Analysis of the SARS-CoV-2 Spike N-Terminal Domain Across Wild-Type and Recent Variants: A Comparative Study.PMID 40485545Read ↗

Conformational and Stability Analysis of SARS-CoV-2 Spike Protein Variants by Molecular SimulationSemantic proximity Read ↗

Dynamics prediction of emerging notable spike protein mutations in SARS-CoV-2 implies a need for updated vaccines.Semantic proximity Read ↗

Evaluation of immune evasion in SARS-CoV-2 Delta and Omicron variantsSemantic proximity Read ↗

Spike protein of SARS-CoV-2 variants: a brief review and practical implications.Semantic proximity Read ↗

What makes SARS‐CoV‐2 unique? Focusing on the spike proteinSemantic proximity Read ↗

Physicochemical effect of the N501Y, E484K/Q, K417N/T, L452R and T478K mutations on the SARS-CoV-2 spike protein RBD and its influence on agent fitness and on attributes developed by emerging variants of concern.Semantic proximity Read ↗

A Comprehensive Analysis of Structural and Functional Changes Induced by SARS-CoV-2 Spike Protein MutationsSemantic proximity Read ↗

Structural basis of Omicron immune evasion: A comparative computational study of Spike protein-Antibody interactionSemantic proximity Read ↗

N-terminal domain mutations of the spike protein are structurally implicated in epitope recognition in emerging SARS-CoV-2 strainsSemantic proximity Read ↗

A Comprehensive Analysis of Structural and Functional Changes Induced by SARS-CoV-2 Spike Protein MutationsSemantic proximity Read ↗

Structural Analysis And Molecular Characteristics of SARSCoV-2 Spike Protein Following S494P Point Mutation: Molecular Dynamics StudySemantic proximity Read ↗

Structural evolution of Delta lineage of SARS-CoV-2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.