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Article

Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants.

Science (New York, N.Y.) - 6 Aug 2021

Cai Yongfei, Zhang Jun, Xiao Tianshu, Lavine Christy L, Rawson Shaun, Peng Hanqin, Zhu Haisun, Anand Krishna, Tong Pei, Gautam Avneesh, Lu Shen, Sterling Sarah M, Walsh Richard M, Rits-Volloch Sophia, Lu Jianming, Wesemann Duane R, Yang Wei, Seaman Michael S, Chen Bing

Abstract excerpt

Several fast-spreading variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the dominant circulating strains in the COVID-19 pandemic. We report here cryo-electron microscopy structures of the full-length spike (S) trimers of the B.1.1.7 and B.1.351 variants, as well as their biochemical and antigenic properties. Amino acid substitutions in the B.1.1.7 protein increase both the...

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Share to Spike Glycoprotein, Coronavirus
Share to Angiotensin-Converting Enzyme 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Antigens, Viral

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Source

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Identifiers

PMID: 34168070
DOI: 10.1126/science.abi9745
PMCID: PMC9245151

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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