Article

Long-lasting astrocyte remodeling in Dravet Syndrome <i>Scn1a</i> <sup>+/–</sup> mouse model

2026-01-06

Abstract excerpt

<h4>Background</h4> Dravet syndrome (DS) is a prototypical developmental and epileptic encephalopathy caused by SCN1A gene mutations leading to NaV1.1 loss of function. The latter causes early-onset drug-resistant seizures and enduring cognitive and behavioral deficits. In this pathological context, the implication of astrocytes remains insufficiently explored. <h4>Methods</h4> Using a heterozygous Scn1a knoc...

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Literature Corpus work: cbf586a9-9272-5d76-8b2b-ede2dc85b8ef
DOI: 10.64898/2026.01.06.697745

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