Article

Astrocyte Ca <sup>2+</sup> Signaling is Facilitated in an <i> Scn1a <sup>+/−</sup> </i> Mouse Model of Dravet Syndrome

2021-05-18

Abstract excerpt

Dravet syndrome (DS) is an infantile-onset epileptic encephalopathy. More than 80% of DS patients have a heterozygous mutation in SCN1A , which encodes a subunit of the voltage-gated sodium channel, Nav 1.1 , in neurons. The roles played by astrocytes, the most abundant glial cell type in the brain, have been investigated in the pathogenesis of epilepsy; however, the specific involvement of astrocytes in DS has...

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Literature Corpus work: a2818102-1b98-54d9-8ff2-b216e80d6202
DOI: 10.1101/2021.05.18.444602

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