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Exogenous Na <sub>V</sub> 1.1 activity in excitatory and inhibitory neurons reverts Dravet syndrome comorbidities when delivered post-symptom onset in mice with Dravet

2022-06-12

Abstract excerpt

Dravet syndrome (DS), an intractable childhood epileptic encephalopathy with a high fatality rate, is caused by loss-of-function mutations in one allele of SCN1A , which encodes Na V 1.1. In contrast to other epilepsies, pharmaceutical treatment for DS is limited. Here, we demonstrate that viral vector-mediated delivery of a codon-modified SCN1A cDNA improves DS comorbidities in juvenile and adolescent DS mice...

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Literature Corpus work
e3355881-ced4-51ce-9016-5648551cb00f
DOI
10.1101/2022.06.10.495591
Open publication

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Exogenous Na <sub>V</sub> 1.1 activity in excitatory and inhibitory neurons reverts Dravet syndrome comorbidities when delivered post-symptom onset in mice with DravetDOI 10.1101/2022.06.10.495591
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