Article

Region-specific spreading depolarization drives aberrant post-ictal behavior

2024-10-12

Abstract excerpt

<h4>Summary</h4> Confusion, aphasia, and unaware wandering are prominent post-ictal symptoms regularly observed in temporal lobe epilepsy (TLE) 1 . Despite the potentially life-threatening nature of the immediate post-ictal state 2 , its neurobiological underpinnings remain understudied 3 . We provide evidence in mice and humans that seizure-associated focal spreading depolarization (sSD) is a pathoclinical ke...

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Literature Corpus work: 6907b1cf-81cd-53b9-9aa0-44db2a94dd34
DOI: 10.1101/2024.10.12.618012

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