Article

High Frequency Oscillations (>250Hz) Outnumber Interictal Spikes in Preclinical Studies of Alzheimer’s Disease

2023-11-02

Abstract excerpt

<h4>ABSTRACT</h4> Interictal spikes (IIS) and seizures are well-documented in Alzheimer’s disease (AD). IIS typically outnumber seizures, supporting their role as a prominent EEG biomarker in AD. In preclinical models, we showed that high frequency oscillations (HFOs>250Hz) also occur, but it is currently unknown how HFOs compare to IIS. Therefore, we asked whether the incidence of HFOs and IIS differed and if th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e72d82d4-fc75-57a1-8789-40e4c394f83f
DOI: 10.1101/2023.10.30.564797

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High Frequency Oscillations (>250Hz) Outnumber Interictal Spikes in Preclinical Studies of Alzheimer’s DiseaseDOI 10.1101/2023.10.30.564797Read

High-frequency oscillations arise through distinct mechanisms in models of α- synucleinopathy and channelopathy-induced epilepsySemantic proximity Read

Interictal Spikes in Alzheimer’s Disease: Preclinical Evidence for Dominance of the Dentate Gyrus and Cholinergic Control by Medial SeptumSemantic proximity Read

Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer’s diseaseSemantic proximity Read

Fast-ripples are emergent properties of neuronal networksSemantic proximity Read

Multitaper Time-frequency Peak-based Longitudinal Sleep Analysis in 5XFAD Mouse ModelSemantic proximity Read

Early Electrophysiological Aberrations in the Hippocampus of the TgF344-AD Rat Model as a Potential Biomarker for Alzheimer’s Disease PrognosisSemantic proximity Read

Early hippocampal hyperexcitability in PS2APP mice: role of mutant PS2 and APP.Semantic proximity Read

Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer’s Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 BlockadeSemantic proximity Read

Photothrombosis induced cortical stroke produces electrographic epileptic biomarkers in miceSemantic proximity Read

Spatiotemporal patterns of high-frequency activity (80-170 Hz) in long-term intracranial EEGSemantic proximity Read

A perfect storm: Converging paths of epilepsy and Alzheimer's dementia intersect in the hippocampal formation.Semantic proximity Read

Waveform-based classification of dentate spikesSemantic proximity Read