Article

Experience-dependent sharp-wave ripple deficits in an Alzheimer’s disease mouse model

2025-06-13

Abstract excerpt

Amyloid pathology is a hallmark of Alzheimer’s disease (AD). Hippocampal sharp-wave ripples (SWRs) play a role in memory consolidation and are impaired in various AD mouse models. However, it remains unclear how experience affects SWRs and how extrinsic signals contribute to SWR generation in AD. Here, by combining behavioral, in vivo electrophysiological and fiber photometry approaches, we show that an experienc...

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Literature Corpus work: 041fd44f-6af6-56d0-a7ce-2b4c2c84cf1d
DOI: 10.1101/2025.06.09.658771

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