Article

Medial septum parvalbumin-expressing inhibitory neurons are impaired in a mouse model of Dravet Syndrome

2024-10-31

Abstract excerpt

<h4>Summary</h4> Dravet syndrome (DS) is a severe neurodevelopmental disorder caused by pathogenic variants in the SCN1A gene, which encodes the voltage-gated sodium channel Na v 1.1 α subunit. Experiments in animal models of DS – including the haploinsufficient Scn1a +/- mouse – have identified impaired excitability of interneurons in the hippocampus and neocortex; this is thought to underlie the treatment-re...

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Literature Corpus work: aa79acf7-fe86-5ad8-8b73-9c10bf7d59ac
DOI: 10.1101/2024.10.29.620933

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