Article

Radiosynthesis and preclinical evaluation of [11C]SNX-ab as an Hsp90α,β isoform-selective PET probe for in vivo brain and tumour imaging

2022-12-12

Abstract excerpt

<title>Abstract</title> <p>Background The molecular chaperone, Hsp90, is a key player in the protein quality control system that maintains homeostasis under cellular stress conditions. It is a homodimer with ATP-dependent activity, and is a prominent member of the chaperone machinery that stabilizes, matures and (re)folds an extensive list of client proteins. Hsp90 occurs as four isoforms, cytosolic Hsp90α and H...

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Literature Corpus work: cbbe514f-89c5-5869-84e5-fbd3e965aa13
DOI: 10.21203/rs.3.rs-2322542/v1

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