Article

The fate of an antibody labelled with zirconium-89 in cynomolgus macaques

2024-04-23

Abstract excerpt

<title>Abstract</title> <p>Background Preclinical pharmacokinetic studies of therapeutic antibodies in non-human primates are desired because of the difficulty in extrapolating ADME data from animal models to humans. We evaluated the pharmacokinetics of <sup>89</sup>Zr-labelled anti-KLH human IgG and its metabolites to confirm their non-specific/physiological accumulation in healthy cynomolgus macaques. Methods...

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Literature Corpus work: 66d0f374-6987-553f-9755-bc099e260d37
DOI: 10.21203/rs.3.rs-4258167/v1

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The fate of an antibody labelled with zirconium-89 in cynomolgus macaquesDOI 10.21203/rs.3.rs-4258167/v1Read

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