Article

Cross-Species Quantitative Benchmarking of SSTR2 Radioligands in Fresh-Frozen Brain Sections: An Adaptable Framework for Radiopharmaceutical Development

2026-03-16

Abstract excerpt

<title>Abstract</title> Rationale Somatostatin receptor subtype 2 (SSTR2) is a G-protein coupled receptor overexpressed in multiple cancers, including neuroendocrine tumors, small cell lung cancer, and hepatocellular carcinoma. Clinical validation of SSTR2-targeted radioligand therapy (Lutathera™) has driven development of next-generation ligands. Progress in next-generation SSTR2 ligand development is streng...

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Literature Corpus work: 37e63d6f-06c6-596e-8bd0-50935d6e6ca7
DOI: 10.21203/rs.3.rs-8981508/v1

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