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Radiosensitization of NET cells by HSP90 inhibitor ganetespib is mediated through pleiotropic stress responses

2025-09-11

Abstract excerpt

<title>Abstract</title> <p> Background Peptide receptor radionuclide therapy (PRRT) employing [ <sup>177</sup> Lu]Lu-[DOTA-Tyr <sup>3</sup> ]octreotate has been established as treatment for patients with metastatic neuroendocrine tumors (NETs) that overexpress the somatostatin receptor (SSTR). While PRRT improves survival and quality of life, curative responses remain rare. One way to enhance PRRT efficacy i...

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Literature Corpus work
0ef63c1f-51fb-5071-823d-dc60421f99e3
DOI
10.21203/rs.3.rs-7271457/v1
Open publication

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Radiosensitization of NET cells by HSP90 inhibitor ganetespib is mediated through pleiotropic stress responsesDOI 10.21203/rs.3.rs-7271457/v1
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