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Article

Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects.

Cancer research - 1 Jan 2008

Chan Carmel T, Paulmurugan Ramasamy, Gheysens Olivier S, Kim Joungnam, Chiosis Gabriela, Gambhir Sanjiv Sam

Abstract excerpt

Heat shock protein 90 alpha (Hsp90 alpha)/p23 and Hsp90 beta/p23 interactions are crucial for proper folding of proteins involved in cancer and neurodegenerative diseases. Small molecule Hsp90 inhibitors block Hsp90 alpha/p23 and Hsp90 beta/p23 interactions in part by preventing ATP binding to Hs...

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Source

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Identifiers

PMID: 18172314
DOI: 10.1158/0008-5472.CAN-07-2268
PMCID: PMC4146344

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18172314-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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