Article

Biodistribution and dosimetry of the PET radioligand [18F]CHDI-650 in mice for detection of mutant huntingtin aggregates

2024-10-07

Abstract excerpt

<title>Abstract</title> Background Huntington’s disease (HD) is a rare neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the huntingtin gene which encodes the mutant huntingtin protein (mHTT) that is associated with HD-related neuropathophysiology. Noninvasive visualization of mHTT aggregates in the brain, with positron emission tomography (PET), will allow to reliably evalu...

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Literature Corpus work: 2c426e33-4e47-5ce9-8243-a6b6a1a1f605
DOI: 10.21203/rs.3.rs-5152047/v1

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