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Article

BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity.

Cell host & microbe - 10 Jan 2018

Arts Rob J W, Moorlag Simone J C F M, Novakovic Boris, Li Yang, Wang Shuang-Yin, Oosting Marije, Kumar Vinod, Xavier Ramnik J, Wijmenga Cisca, Joosten Leo A B, Reusken Chantal B E M, Benn Christine S, Aaby Peter, Koopmans Marion P, Stunnenberg Hendrik G, van Crevel Reinout, Netea Mihai G

Abstract excerpt

The tuberculosis vaccine bacillus Calmette-Guérin (BCG) has heterologous beneficial effects against non-related infections. The basis of these effects has been poorly explored in humans. In a randomized placebo-controlled human challenge study, we found that BCG vaccination induced genome-wide epigenetic reprograming of monocytes and protected against experimental infection with an attenuated yellow fever virus...

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Identifiers

PMID: 29324233
DOI: 10.1016/j.chom.2017.12.010

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