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Article

Neonatal BCG vaccination is associated with a long-term DNA methylation signature in circulating monocytes

5 Aug 2022

Abstract excerpt

Trained immunity describes the capacity of innate immune cells to develop heterologous memory in response to certain exogenous exposures. This phenomenon mediates, at least in part, the beneficial off-target effects of the BCG vaccine. Using an in vitro model of trained immunity, we show that BCG exposure induces a persistent change in active histone modifications, DNA methylation, transcription, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35930640
DOI: 10.1126/sciadv.abn4002

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