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Article

Differential DNA methylation of potassium channel KCa3.1 and immune signalling pathways is associated with infant immune responses following BCG vaccination.

Scientific reports - 30 Aug 2018

Hasso-Agopsowicz Mateusz, Scriba Thomas J, Hanekom Willem A, Dockrell Hazel M, Smith Steven G

Abstract excerpt

Bacillus Calmette-Guérin (BCG) is the only licensed vaccine for tuberculosis (TB) and induces highly variable protection against pulmonary disease in different countries. We hypothesised that DNA methylation is one of the molecular mechanisms driving variability in BCG-induced immune responses. DNA methylation in peripheral blood mononuclear cells (PBMC) from BCG vaccinated infants was measured and comparisons...

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Identifiers

PMID: 30166570
DOI: 10.1038/s41598-018-31537-9
PMCID: PMC6117309

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