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Article

Origin of the GPR15LG–GPR15 signaling axis in ancient fish ancestors

2026-06-04

Abstract excerpt

The chemokine-like peptide GPR15LG is a known agonist of G protein-coupled receptor 15 (GPR15), a ligand–receptor pair primarily implicated in mammalian mucosal immunity and lymphocyte homing. However, the evolutionary origin and phylogenetic distribution of this signaling system remain poorly understood due to the extreme sequence diversity of GPR15LG orthologs. In this study, we identified GPR15LG orthologs in s...

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Literature Corpus work
cb9a448a-ee32-5828-b06f-f9fdd25ea42f
DOI
10.64898/2026.06.02.729464
Open publication

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Origin of the GPR15LG–GPR15 signaling axis in ancient fish ancestorsDOI 10.64898/2026.06.02.729464
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