Article

Evolutionary conservation and divergence of CXCL17 orthologs: functional evidence in reptiles and loss in the avian lineage

2026-05-18

Abstract excerpt

<h4>ABSTRACT</h4> The mucosal chemoattractant C-X-C motif chemokine ligand 17 (CXCL17) was recently identified as a ligand for the orphan G protein-coupled receptor 25 (GPR25). Although our recent studies have identified non-mammalian CXCL17 orthologs in fishes and amphibians, their presence in reptiles and birds remains unclear. In this study, we employed bioinformatic searches based on gene synteny and sequence...

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Literature Corpus work: 1b20a66f-815f-587a-8580-685abb0f2737
DOI: 10.64898/2026.05.18.725876

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