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Article

Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15

25 Jun 2024

Abstract excerpt

The atypical chemoattractant receptor GPR15, a class-A GPCR, is significantly involved in colorectal cancer pathogenesis and the maintenance of intestinal immune homeostasis. Originally identified as a co-receptor for human immunodeficiency virus (HIV) or simian immunodeficiency virus (SIV), GPR15 regulates the targeted homing of T cells, notably FOXP3 + regulatory T cells (Tregs), to the lamina propria of the...

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PMID: 38918398
DOI: 10.1038/s41421-024-00698-5

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