Article

The first functional characterization of ancient interleukin-15-like (IL-15L) reveals shared and distinct functions of the IL-2, -15 and -15L family cytokines

2019-05-23

Abstract excerpt

The ancient cytokine interleukin 15-like (IL-15L) was lost in humans and mice but not throughout mammals. This is the first study to describe IL-15L functions, namely in the fish rainbow trout. Fish have only one α-chain receptor gene IL-15Rα , whereas in mammalian evolution this gene duplicated and evolved into IL-15Rα plus IL-2Rα . Trout IL-2, IL-15 and IL-15L all could bind IL-15Rα and were able to induce ph...

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Literature Corpus work: 2ff0e4f8-a0c3-58a9-b1e9-c75ddf0ed0b4
DOI: 10.1101/644955

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