Article

Parkinson disease-associated protein DJ-1 regulates the autophagic-lysosomal pathway through ROS-dependent modulation of the AMPK/mTORC1 axis

2026-04-13

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the protein DJ-1 are linked to familial forms of Parkinson’s disease (PD). The protein has been well-documented to exert a role in energy metabolism and antioxidant defense, contributing to the maintenance of mitochondrial homeostasis. We and others have previously observed that DJ-1 can also influence autophagy, but the mechanisms are still incompletely defined. In this study, usin...

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Literature Corpus work: cb8b6a9d-feac-5bd8-895e-83081b8f8664
DOI: 10.64898/2026.04.09.717467

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