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Article

DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses

14 Jan 2009

Abstract excerpt

In cancer, DJ-1/PARK7 acts as an oncogene that drives Akt-mediated cell survival. Although amplification of DJ-1 has been described in several types of tumors, the mechanistic basis of DJ-1's oncogenic effect remains incompletely understood. A tumor's ability to adapt to hypoxia is absolutely critical for its survival and progression, and this adaptation is largely mediated by the transcription factor HIF1. The...

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PMID: 19144925
DOI: 10.1073/pnas.0812745106

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