Article
Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1.
PloS one - 23 Feb 2010
Krebiehl Guido, Ruckerbauer Sabine, Burbulla Lena F, Kieper Nicole, Maurer Brigitte, Waak Jens, Wolburg Hartwig, Gizatullina Zemfira, Gellerich Frank N, Woitalla Dirk, Riess Olaf, Kahle Philipp J, Proikas-Cezanne Tassula, Krüger Rejko
Abstract excerpt
BACKGROUND: Mitochondrial dysfunction and degradation takes a central role in current paradigms of neurodegeneration in Parkinson's disease (PD). Loss of DJ-1 function is a rare cause of familial PD. Although a critical role of DJ-1 in oxidative stress response and mitochondrial function has been recognized, the effects on mitochondrial dynamics and downstream consequences remain to be determined....
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