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Article

The Parkinson's-associated protein DJ-1 regulates the 20S proteasome.

Nature communications - 2 Apr 2015

Moscovitz Oren, Ben-Nissan Gili, Fainer Irit, Pollack Dan, Mizrachi Limor, Sharon Michal

Abstract excerpt

The Parkinson's-associated protein, DJ-1, is a highly conserved homodimer, ubiquitously expressed in cells. Here we demonstrate that DJ-1 is a 20S proteasome regulator. We show that DJ-1 physically binds the 20S proteasome and inhibits its activity, rescuing partially unfolded proteins from degradation. Consequently, DJ-1 stabilizes the cellular levels of 20S proteasome substrates, as we show for α-synuclein and...

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Identifiers

PMID: 25833141
DOI: 10.1038/ncomms7609

Genes

NQO1

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