Article
DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.
Human molecular genetics - 1 Jan 2011
Thomas Kelly Jean, McCoy Melissa K, Blackinton Jeff, Beilina Alexandra, van der Brug Marcel, Sandebring Anna, Miller David, Maric Dragan, Cedazo-Minguez Angel, Cookson Mark R
Abstract excerpt
Mutations in DJ-1, PINK1 (PTEN-induced putative kinase 1) and parkin all cause recessive parkinsonism in humans, but the relationships between these genes are not clearly defined. One event associated with loss of any of these genes is altered mitochondrial function. Recent evidence suggests that turnover of damaged mitochondria by autophagy might be central to the process of recessive parkinsonism. Here, we show...
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