Inactivation of <i>Drosophila</i> DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling

Abstract excerpt

Parkinson's disease (PD) is the most common movement disorder characterized by dopaminergic dysfunction and degeneration. The cause of most PD cases is unknown, although postmortem studies have implicated the involvement of oxidative stress. The identification of familial PD-associated genes offers the opportunity to study mechanisms of PD pathogenesis in model organisms. Here, we show that DJ-1A, a Drosophila...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Insect Resistance and Genetics
• Share to Neurobiology and Insect Physiology Research
• Share to Parkinson's Disease Mechanisms and Treatments