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Integrated multi-omics reveals cellular and molecular interactions governing the invasive niche of basal cell carcinoma

20 Aug 2022

Abstract excerpt

Tumors invade the surrounding tissues to progress, but the heterogeneity of cell types at the tumor-stroma interface and the complexity of their potential interactions hampered mechanistic insight required for efficient therapeutic targeting. Here, combining single-cell and spatial transcriptomics on human basal cell carcinomas, we define the cellular contributors of tumor progression. In the invasive niche,...

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PMID: 35986012
DOI: 10.1038/s41467-022-32670-w

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