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Spatial Transcriptomics Suggests That Alterations Occur in the Preneoplastic Breast Microenvironment of BRCA1/2 Mutation Carriers.

Molecular cancer research : MCR - 1 Feb 2024

Caputo Anthony, Vipparthi Kavya, Bazeley Peter, Downs-Kelly Erinn, McIntire Patrick, Duckworth Lauren A, Ni Ying, Hu Bo, Keri Ruth A, Karaayvaz Mihriban

Abstract excerpt

Breast cancer is the most common cancer in females, affecting one in every eight women and accounting for the majority of cancer-related deaths in women worldwide. Germline mutations in the BRCA1 and BRCA2 genes are significant risk factors for specific subtypes of breast cancer. BRCA1 mutations are associated with basal-like breast cancers, whereas BRCA2 mutations are associated with luminal-like disease....

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PMID: 37878345
DOI: 10.1158/1541-7786.MCR-23-0489
PMCID: PMC10872731

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