Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma.

doi:10.1016/j.cell.2021.12.023

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Article

Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma.

Cell - 20 Jan 2022

Risom Tyler, Glass David R, Averbukh Inna, Liu Candace C, Baranski Alex, Kagel Adam, McCaffrey Erin F, Greenwald Noah F, Rivero-Gutiérrez Belén, Strand Siri H, Varma Sushama, Kong Alex, Keren Leeat, Srivastava Sucheta, Zhu Chunfang, Khair Zumana, Veis Deborah J, Deschryver Katherine, Vennam Sujay, Maley Carlo, Hwang E Shelley, Marks Jeffrey R, Bendall Sean C, Colditz Graham A, West Robert B, Angelo Michael

Abstract excerpt

Ductal carcinoma in situ (DCIS) is a pre-invasive lesion that is thought to be a precursor to invasive breast cancer (IBC). To understand the changes in the tumor microenvironment (TME) accompanying transition to IBC, we used multiplexed ion beam imaging by time of flight (MIBI-TOF) and a 37-plex antibody staining panel to interrogate 79 clinically annotated surgical resections using machine learning tools for...

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Identifiers

PMID: 35063072
DOI: 10.1016/j.cell.2021.12.023
PMCID: PMC8792442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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