Article

Genome-wide maps of transcription factor footprints identify noncoding variants rewiring gene regulatory networks

2026-03-05

Abstract excerpt

Genome-wide association studies have identified millions of noncoding loci linked to human traits, yet how these variants alter gene regulation remains a major challenge, particularly for rare variants where whole-genome sequencing cohorts and high-resolution functional annotations remain limited. Here we show that single-molecule deaminase footprinting (FOODIE) in K562 cells captures up to 103-fold heritability e...

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Literature Corpus work: cb59cdbf-4d8e-5e24-baba-c12f1022ef1e
DOI: 10.64898/2026.03.03.708783

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